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Solutions for

IV bags

IV bags are commonly manufactured in large quantities for the delivery of infusion solutions, electrolytes, nutrients and pharmaceutical formulations. Once filled and sealed, the complete product-container system must reach the required sterility assurance without compromising the formulation, the flexible bag, its seals or its ports.

For high-volume lines, the challenge extends to the economics and continuity of the complete production flow. Process time, bags per batch, loading and unloading, utility demand, water and wastewater, drying and downstream readiness all influence line output and cost per processed bag. The sterilization strategy must therefore protect product and container quality while preventing the post-filling process from becoming a production bottleneck.


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3D schematic illustration of a red cube featuring three callout badges: "High-capacity processing" at the top left, "No handling bottleneck" on the right, and "Water recovery system" at the bottom left.

WE COMBINE SUPERHEATED-WATER OR STEAM-AIR TERMINAL STERILIZATION WITH AUTOMATED OR ROBOTIC HANDLING.

Configuring the complete system around the production priorities of the iv bag line.

Superheated water sterilization provides rapid heating and cooling when high heat-transfer performance and high-capacity processing are decisive. Steam-air reduces process-water demand, wastewater and operating costs while enabling dry unloading. Independent pressure and temperature control protects flexible bags, seals and ports throughout heating and cooling.

Automated load preparation, arrangement, loading and unloading preserve a repeatable load geometry, essential for consistent heat transfer, airflow and thermal exposure across the entire load. Load tracking and recipe management maintain the link between each configuration and its validated process. Faster transfers, reduced manual intervention and direct delivery to inspection or packaging improve sterilizer utilization and overall line performance.

IV BAGS MANUFACTURING

Solution for IV BAGS Fedegari

FEDEGARI SOLUTIONS FOR IV BAGS

APPLICATION NUMBERS

Up to 6,000
bags per hour - production line throughput

60-90 min
cycle duration according to the specific load configuration

Up to 0,77
seconds per bags handling speed

0
process water consumption thanks to recovery systems with auxiliary tanks

FREQUENTLY ASKED QUESTIONS

How does Fedegari select the most suitable IV bag sterilization process?

A risk-based assessment considers the bag, fill, headspace, seals, product sensitivity, required lethality, load, output, water impact and downstream operations. Representative bags can then be tested at Fedegari Tech Centers before the industrial process is finalized.

Why is superheated-water sterilization widely used for IV bags?

Superheated water provides rapid, homogeneous heating and cooling for high-capacity loads. Comparable exposure across load positions supports consistent lethality, while shorter transitions can limit unnecessary thermal stress on the product. The load exits wet, an acceptable trade-off when output and cost per bag are the main priorities.

When should steam-air sterilization be considered for IV bags?

Steam-air becomes attractive when lower water use, reduced wastewater and utility demand or dry unloading create greater value across the line. Continuous ventilation limits stratification and stagnant areas, while dry bags can move more directly to inspection, leak detection, labelling and packaging.

How are flexible IV bags protected during terminal sterilization?

As the liquid heats and cools, pressure inside the bag changes. Controlled chamber counterpressure balances these variations throughout heating, exposure and cooling, helping protect bag geometry, seals and ports from excessive swelling, deformation, leakage or rupture.

Why is automatic handling important in IV bag sterilization?

High batch capacity becomes line throughput only when loads are prepared, transferred and discharged consistently. Automated handling protects the bags and validated arrangement, while identification and tracking preserve the association between each batch, its load configuration, selected sterilization route and downstream handover.

Knowledge Hub Regulatory

Aseptic Transfer: The fragile points of sterility Where process design determines whether sterility holds - or fails

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Immagine aseptic Transfer-2

Customer so closer is not a promise of proximity
It is a way of working.

A global network designed to keep Fedegari close to the customer, close to the process and close to the decisions that make sterile manufacturing safer, more reliable and more valuable over time.