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Combined
sterilization and decontamination

Modern pharmaceutical facilities must support an increasing variety of materials, production scenarios and transfer requirements. This demands access to both sterilization and surface decontamination: two distinct processes serving different treatment needs.

Traditionally, providing both capabilities requires an autoclave and a separate H₂O₂ pass box, increasing classified footprint, equipment interfaces and the number of systems to qualify, integrate and maintain.

This is especially critical in multi-product and brownfield facilities, where production requirements continue to evolve but classified space and existing infrastructure cannot expand at the same pace: more treatment flexibility cannot mean more infrastructure anymore.


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COMBINED STERILIZATION AND DECONTAMINATION INTEGRATES STEAM STERILIZATION AND H₂O₂ SURFACE DECONTAMINATION WITHIN THE SAME CHAMBER WHILE PRESERVING A DEDICATED CONTROL STRATEGY FOR EACH PROCESS.

The chamber is shared. each process retains its own control strategy.

Steam sterilization is governed through pressure-based control, multi-point temperature monitoring and configurable Phase Groups. H₂O₂ surface decontamination is controlled through direct concentration measurement and feedback, with defined exposure and aeration conditions.

Digitally controlled cooling flows and valves establish the chamber conditions required for the selected treatment. Non-proprietary H₂O₂ solutions also preserve customer freedom in process development and sourcing.

Key advantages of Fedegari FOFH combined steam sterilizer and H2O2 bio-decontamination chamber
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EXPAND TREATMENT CAPABILITY WITHOUT EXPANDING CLASSIFIED SPACE

Steam sterilization and H₂O₂ surface decontamination are performed in the same chamber, eliminating the need for a separate pass-box.

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REDUCE QUALIFICATION AND LIFECYCLE BURDEN

One combined platform reduces the number of systems, process interfaces and maintenance strategies required to provide both treatment capabilities.

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MAINTAIN FREEDOM IN H₂O₂ SOURCING

No proprietary hydrogen peroxide solution is required. Customers select the H₂O₂ supplier according to their validated process.

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RELIABLE OUTCOMES ACROSS BOTH TREATMENTS

Pressure-based control, multi-point RTD monitoring and modular Phase Groups govern steam cycles. Direct H₂O₂ concentration measurement and feedback control loop govern surface-decontamination cycles.

DEDICATED PROCESS CONTROL FUNCTIONS

Pressure-based control, multi-point RTD monitoring and modular Phase Groups govern steam penetration, temperature uniformity and drying.

Digital control of cooling flows and valves prepares the chamber for the H₂O₂ cycle. Dual-sensor feedback controls H₂O₂ concentration, while settable exposure and aeration phases govern surface decontamination and residual removal.

Proven by numbers

PROVEN BY NUMBERS

1 ppm
typical aeration target

5–10
minutes Chamber dehumidification time

800 ppm
typical H₂O₂ concentration

WHEN SHOULD YOU CHOOSE OUR TECHNOLOGY

MULTI-PRODUCT FACILITIES

Support different load families and evolving production scenarios, making both steam sterilization and H₂O₂ surface decontamination available without multiplying dedicated equipment. 

BROWNFIELD AND SPACE-CONSTRAINED PROJECTS

Add H₂O₂ surface decontamination alongside steam sterilization when classified space or existing infrastructure does not allow the installation of a separate pass box.

TRANSFER INTO STERILITY-TEST ISOLATORS

Provide the appropriate treatment for each material entering a sterility-test isolator—from steam sterilization to H₂O₂ surface decontamination—through one integrated access point.

FREQUENTLY ASKED QUESTIONS

Why choose combined sterilization and decontamination instead of separate equipment?

Combined Sterilization and Decontamination provides both capabilities without requiring a dedicated H₂O₂ pass-box, reducing equipment count, classified footprint and lifecycle burden.

 

Which materials can undergo H₂O₂ surface decontamination?

Compatible heat-sensitive materials, presterilized components and external packaging surfaces can be treated according to the validated cycle.

 

 

Is a proprietary H₂O₂ solution required?

No. Customers can select any supplier for the aqueous hydrogen peroxide solution.

 

 

Does Combined Sterilization and Decontamination Retain Standard Autoclave Capabilities?

Yes. Combined Sterilization and Decontamination performs the saturated-steam cycles of a standard autoclave while adding H₂O₂ surface decontamination.

Can both treatments be performed in the ame chamber?

Yes. The appropriate cycle is selected according to the treatment requirements of each load.

Is H₂O₂ used for sterilization or surface decontamination?

In Combined Sterilization and Decontamination applications, H₂O₂ is used for surface decontamination. Saturated steam remains the sterilization technology.

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